Endocrine Abstracts

Endothelial cells (ECs) have major role in post-ischemic angiogenesis. Trimethylation of lysine 27 of histone3 (H3K27me3) is a repressive epigenetic mark carried by EZH2 enzyme, the catalytic part of Polycomb complex2 (PRC2, also comprising the suppressor of zeste 12 homolog (Suz12)). We investigated if in vitro hypoxia and in vivo limb ischemia affect the expression of PRC2 in ECs and mouse limb muscles, respectively. Then, modulation of angiogenic genes by ...